Short alkylated peptoid mimics of antimicrobial lipopeptides.
نویسندگان
چکیده
We report the creation of alkylated poly-N-substituted glycine (peptoid) mimics of antimicrobial lipopeptides with alkyl tails ranging from 5 to 13 carbons. In several cases, alkylation significantly improved the selectivity of the peptoids with no loss in antimicrobial potency. Using this technique, we synthesized an antimicrobial peptoid only 5 monomers in length with selective, broad-spectrum antimicrobial activity as potent as previously reported dodecameric peptoids and the antimicrobial peptide pexiganan.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 55 1 شماره
صفحات -
تاریخ انتشار 2011